Induction of Labour vs Expectant Management for Preterm Rupture of Membranes
Author Information
Author(s): van der Ham David P, Nijhuis Jan G, Mol Ben Willem J, van Beek Johannes J, Opmeer Brent C, Bijlenga Denise, Groenewout Mariette, Arabin Birgit, Bloemenkamp Kitty WM, van Wijngaarden Wim J, Wouters Maurice GAJ, Pernet Paula JM, Porath Martina M, Molkenboer Jan FM, Derks Jan B, Kars Michael M, Scheepers Hubertina CJ, Weinans Martin JN, Woiski Mallory D, Wildschut Hajo IJ, Willekes Christine
Primary Institution: null
Hypothesis
Does immediate delivery after preterm prelabour rupture of membranes reduce the risk of neonatal sepsis compared to expectant management?
Conclusion
The trial aims to determine if induction of labour is an effective strategy to reduce neonatal sepsis risk.
Supporting Evidence
- The incidence of neonatal sepsis is 2.5% with immediate delivery compared to 7.5% with expectant management.
- The study aims to include 520 women to achieve sufficient statistical power.
- Previous studies showed trends towards better outcomes with induction but lacked statistical significance.
Takeaway
This study is trying to find out if delivering babies right away after their mothers' water breaks is better than waiting, especially to prevent infections.
Methodology
A multicentre prospective randomised controlled trial comparing early delivery with expectant monitoring.
Potential Biases
Potential bias due to non-blinding of participants and healthcare providers.
Limitations
The study may not be able to blind participants or healthcare workers to the treatment allocation.
Participant Demographics
Pregnant women with preterm prelabour rupture of membranes between 34+0 and 37+0 weeks gestation.
Statistical Information
P-Value
0.05
Confidence Interval
null
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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