Caffeine withdrawal retains anticataleptic activity but Withania somnifera withdrawal potentiates haloperidol-induced catalepsy in mice
2008
Caffeine and Withania somnifera Withdrawal Effects on Catalepsy in Mice
publication
Evidence: moderate
Author Information
Author(s): Dandge YB, Barhate Shrikant A, Kasture SB, M Mohan
Primary Institution: MGV’s Pharmacy College, Panchavati, Nashik, India
Hypothesis
Caffeine and Withania somnifera may be useful adjuvants in pharmacotherapy for Parkinson's disease.
Conclusion
Caffeine withdrawal retains anticataleptic activity, while Withania somnifera withdrawal potentiates haloperidol-induced catalepsy.
Supporting Evidence
- Single administration of both WS and caffeine significantly inhibited catalepsy.
- Mice withdrawn from caffeine significantly inhibited haloperidol-induced catalepsy.
- Mice withdrawn from WS showed increased catalepsy.
Takeaway
Caffeine helps prevent catalepsy when you stop using it, but stopping Withania somnifera can make catalepsy worse.
Methodology
Mice were treated with Withania somnifera and caffeine, followed by withdrawal and assessment of catalepsy induced by haloperidol.
Participant Demographics
Albino mice
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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