Distribution and clinicopathological characteristics of G-CSF expression in tumor cells and stromal cells in upper tract urothelial carcinoma

2025

G-CSF Expression in Upper Tract Urothelial Carcinoma

Sample size: 112 publication 10 minutes Evidence: high

Author Information

Author(s): Kobayashi Go, Sekino Yohei, Nakahara Hikaru, Kobatake Kohei, Goto Keisuke, Hayashi Tetsutaro, Sentani Kazuhiro, Hinata Nobuyuki

Primary Institution: Hiroshima University

Hypothesis

The study aims to clarify the clinicopathological significance of G-CSF expression in upper tract urothelial carcinoma (UTUC).

Conclusion

G-CSF expression in tumor and stromal cells is associated with poor prognosis in UTUC, suggesting its potential as a prognostic marker.

Supporting Evidence

G-CSF expression was significantly higher in tumor tissues compared to normal urothelium.
G-CSF expression in stromal cells was associated with poor prognosis.
Stromal G-CSF expression was an independent prognostic factor.
High G-CSF expression correlated with advanced tumor stage and high grade.
Patients with G-CSF positive stromal cells had significantly lower cancer-specific survival.

Takeaway

This study found that a protein called G-CSF is more common in cancer cells of the urinary tract and can help doctors predict how serious the cancer might be.