Geographic Linkage and Variation in Cryptosporidium hominis
Author Information
Author(s): Chalmers Rachel M., Hadfield Stephen J., Jackson Colin J., Elwin Kristin, Xiao Lihua, Hunter Paul
Primary Institution: National Public Health Service Microbiology, Swansea, Wales, UK
Hypothesis
Is there a link between Cryptosporidium hominis subtypes and recent travel outside Europe?
Conclusion
The study found that non-IbA10G2 subtypes of Cryptosporidium hominis are significantly linked to recent travel outside Europe.
Supporting Evidence
- Nine subtypes of Cryptosporidium hominis were identified, with IbA10G2 being the most common.
- 55.6% of individuals with non-IbA10G2 subtypes reported recent foreign travel.
- The study found a significant link between subtype and foreign travel outside Europe.
Takeaway
This study looked at a type of germ that can make people sick and found that people who got it after traveling outside Europe had different types than those who didn't travel.
Methodology
The study sequenced the GP60 locus from 115 Cryptosporidium hominis isolates collected during a case-control study.
Limitations
The GP60 sequence typing had very low discriminatory power for UK C. hominis isolates.
Participant Demographics
Isolates were collected from human cases of cryptosporidiosis in Wales and northwest England.
Statistical Information
P-Value
p = 0.00008
Confidence Interval
95% CI 4.76–303.65
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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