Lymphopenia as a Prognostic Factor in Peripheral T-Cell Lymphoma
Author Information
Author(s): Kim Yu Ri, Kim Jin Seok, Kim Soo Jeong, Jung Hyun Ae, Kim Seok Jin, Kim Won Seog, Lee Hye Won, Eom Hyeon Seok, Jeong Seong Hyun, Park Joon Seong, Cheong June-Won, Min Yoo Hong
Primary Institution: Yonsei University College of Medicine
Hypothesis
Does lymphopenia at diagnosis adversely affect survival in patients with PTCL-NOS treated with anthracycline-containing chemotherapy?
Conclusion
Lymphopenia is an independent prognostic marker for predicting unfavorable overall survival and progression-free survival in patients with PTCL-NOS treated with anthracycline-containing chemotherapy.
Supporting Evidence
- Patients with lymphopenia had shorter overall survival and progression-free survival rates compared to those with high absolute lymphocyte counts.
- Treatment-related mortality was significantly higher in the low ALC group compared to the high ALC group.
- Lymphopenia was associated with high-intermediate/high-risk IPI scores, indicating a poorer prognosis.
Takeaway
If a patient has low lymphocyte levels when diagnosed with a type of lymphoma called PTCL-NOS, they might not live as long or do as well with treatment.
Methodology
The study included 118 patients with PTCL-NOS treated with anthracycline-containing chemotherapy, and their medical records were reviewed for demographics and clinical outcomes.
Potential Biases
Potential biases due to the retrospective nature of the study and exclusion of patients who did not receive chemotherapy.
Limitations
The study was retrospective, and treatment regimens were not identical across patients.
Participant Demographics
The study group consisted of 79 males (66.9%) and 39 females (33.0%) with a median age of 56 years.
Statistical Information
P-Value
0.003
Confidence Interval
95% CI 2.40-6.84 for IPI; 95% CI 1.33-3.78 for lymphopenia
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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