Creating Biodegradable Magnetic Microspheres for Drug Delivery
Author Information
Author(s): Zhao Hong, Gagnon Jeffrey, Häfeli Urs O
Primary Institution: Faculty of Pharmaceutical Sciences, The University of British Columbia
Hypothesis
Can biodegradable sustained release magnetite microspheres be effectively prepared for vascular administration?
Conclusion
The study successfully demonstrated that biodegradable PLGA microspheres can be created with controlled size and similar properties, whether magnetic or non-magnetic.
Supporting Evidence
- The size of the microspheres can be controlled by modifying the homogenization speed and formulation variables.
- Magnetic microspheres were found to have similar size and morphology to non-magnetic microspheres.
- The study utilized a double emulsion solvent evaporation method for microsphere preparation.
Takeaway
The researchers made tiny, biodegradable balls that can carry medicine and be guided to specific places in the body using magnets.
Methodology
Microspheres were prepared using a water-in-oil-in-water double emulsion solvent evaporation method, with various formulation and processing parameters systematically investigated.
Limitations
The encapsulation of pharmacologically active drugs into the PLGA MMS was not investigated in this study.
Digital Object Identifier (DOI)
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