[(2S,5R)-1-Methyl-5-phenylpyrrolidin-2-yl]diphenylmethanol
2011
Crystal Structure of a Chiral Compound
publication
Evidence: moderate
Author Information
Author(s): Zukerman-Schpector Julio, Venturini Moro Angélica, Lüdtke Diogo S., Correia Carlos Roque D., Tiekink Edward R. T.
Primary Institution: Universidade Federal de São Carlos
Hypothesis
The study aims to analyze the crystal structure of a new chiral ligand for the highly enantioselective addition of arylzinc reagents to aldehydes.
Conclusion
The crystal structure analysis confirms the expected syn relationship between the phenyl and diphenylmethanol substituents.
Supporting Evidence
- The phenyl and diphenylmethanol substituents are syn to each other.
- The pyrrolidine ring has an envelope conformation.
- The hydroxy group forms an intramolecular hydrogen bond with the pyrrolidine N atom.
- The crystal packing features C—H⋯π interactions.
Takeaway
The researchers looked at the structure of a special molecule that helps in making other chemicals in a very specific way.
Methodology
The study involved crystal structure analysis using X-ray diffraction techniques.
Digital Object Identifier (DOI)
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