Optimal Indocyanine Green Dosage for Laparoscopic Colorectal Surgery
Author Information
Author(s): Son Gyung Mo, Park Sang-Ho, Kim Nam Su, Yun Mi Sook, Lee In Young, Kwon Myeong-Sook, Kim Tae Kyun, Lee Eun Hwa, Hwang Eun Jung, Baek Kwang-Ryul, Dambrauskas Zilvinas
Primary Institution: Pusan National University Yangsan Hospital
Hypothesis
What is the minimal effective dose of indocyanine green (ICG) required for accurately assessing colonic perfusion during laparoscopic colorectal surgery?
Conclusion
The study supports using minimal ICG doses of 0.02 to 0.05 mg/kg to optimize repetitive ICG angiography during laparoscopic colorectal surgery.
Supporting Evidence
- Group 1 (0.01 mg/kg) had significantly lower analysis accessibility rates compared to Groups 2-5.
- The mean slope value in Group 1 was significantly lower than in the other groups.
- Washout time was significantly faster with minimal doses compared to conventional doses.
Takeaway
Doctors found that using a smaller amount of a special dye called indocyanine green helps them see how well blood is flowing in the colon during surgery, making it safer for patients.
Methodology
The study involved 15 patients with colorectal cancer undergoing laparoscopic right hemicolectomy, where various doses of ICG were administered and analyzed for perfusion.
Potential Biases
Potential bias due to the small sample size and specific camera technology used.
Limitations
The study had a small sample size and results may not be generalizable to all laparoscopic NIR camera systems.
Participant Demographics
Patients aged 19 to 80 years, with a mix of males and females, classified as ASA Grade 1 or 2.
Statistical Information
P-Value
p < 0.001
Statistical Significance
p < 0.001
Digital Object Identifier (DOI)
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