Effects of Gastrodia Elata Bl on Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice
2011
Effects of Gastrodia Elata on Schizophrenia-Like Symptoms in Mice
Sample size: 12
publication
Evidence: moderate
Author Information
Author(s): Shin E.-J, Kim J.-M, Nguyen X.-K. T, Nguyen T.-T. L, Lee S. Y, Jung J.-H, Kim M. J, Whang W. K, Yamada K, Nabeshima T, Kim H.-C
Primary Institution: Kangwon National University
Hypothesis
Can Gastrodia elata Bl affect phencyclidine-induced abnormal behavior in mice?
Conclusion
Gastrodia elata Bl significantly reduces schizophrenia-like symptoms induced by phencyclidine in mice.
Supporting Evidence
- PCP treatment increased immobility and decreased social interaction in mice.
- Gastrodia elata treatment reduced these PCP-induced behaviors.
- The effects of Gastrodia elata were similar to those of a known 5-HT1A receptor agonist.
Takeaway
This study found that a plant called Gastrodia elata can help mice behave more normally after being given a drug that makes them act like they have schizophrenia.
Methodology
Mice were treated with phencyclidine and then given Gastrodia elata to observe changes in behavior.
Participant Demographics
Male C57BL/6J and ICR mice, weighing 25±3 g.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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