Gallbladder Cancer in Patients with Gallstones
Author Information
Author(s): Muacevic Alexander, Adler John R, Alam Muhammad, Anwar Asma, Qureshi Hikmat Ullah, Khan Muhammad Bilawal, Deeba Farah, Khan Ali Gohar
Primary Institution: Hayatabad Medical Complex, Peshawar
Hypothesis
What is the prevalence of incidental gallbladder carcinoma in patients undergoing cholecystectomy for symptomatic cholelithiasis?
Conclusion
Incidental gallbladder carcinoma was found in 3.04% of patients undergoing cholecystectomy for symptomatic cholelithiasis, with longer symptom duration and older age as significant risk factors.
Supporting Evidence
- 7 out of 230 patients (3.04%) had incidental gallbladder carcinoma.
- 5 cases were adenocarcinoma and 2 were papillary carcinoma.
- Patients with incidental carcinoma had a longer symptom duration (mean: 14.2 months).
- Older age was a significant risk factor for incidental carcinoma.
Takeaway
Some people who have their gallbladder removed for stones might actually have cancer in it, even if no one suspected it before surgery.
Methodology
This retrospective cohort study reviewed records of 230 patients who underwent cholecystectomy for symptomatic cholelithiasis, with histopathological examination of excised gallbladders.
Potential Biases
Potential reporting bias and missing data due to the retrospective design.
Limitations
The study was conducted at a single center, which may affect the generalizability of the findings, and had a small number of carcinoma cases.
Participant Demographics
Patients aged 18-55 years, with a mean age of 40.7 years; 67.8% female and 32.2% male.
Statistical Information
P-Value
0.001
Statistical Significance
p ≤ 0.05
Digital Object Identifier (DOI)
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