Prognostic Utility of the Modified Systemic Inflammation Score for Oral Cavity Cancer Surgery
Author Information
Author(s): Fang Ku-Hao, Lo Sheng-Wei, Kudva Adarsh, De Vito Andrea, Tsai Yuan-Hsiung, Hsu Cheng-Ming, Chang Geng-He, Huang Ethan I., Tsai Ming-Shao, Tsai Ming-Hsien, Liao Chun-Ta, Kang Chung-Jan, Tsai Yao-Te
Primary Institution: Chang Gung Memorial Hospital
Hypothesis
The modified systemic inflammation score (mSIS) effectively indicates prognosis in patients with oral cavity squamous cell carcinoma (OCSCC) undergoing surgery.
Conclusion
The mSIS reliably predicts overall survival and disease-free survival in OCSCC patients undergoing surgery.
Supporting Evidence
- High preoperative mSIS scores correlate with unfavorable clinicopathological features.
- Kaplan–Meier analysis showed that a high mSIS is associated with lower 5-year overall survival and disease-free survival rates.
- Multivariable analysis confirmed mSIS = 2 as an independent risk factor for both disease-free survival and overall survival.
Takeaway
Doctors can use a score called mSIS to help predict how well patients with mouth cancer will do after surgery.
Methodology
The study retrospectively reviewed data from 320 OCSCC patients who underwent curative surgery, classifying them based on preoperative lymphocyte-to-monocyte ratio and serum albumin levels.
Potential Biases
Potential selection bias due to the retrospective nature of the study.
Limitations
The study's retrospective, single-center design may introduce selection bias, and the prognostic value of mSIS was not validated with an independent dataset.
Participant Demographics
Most participants were male (90.3%), with a median age of 61 years, and 63.4% were younger than 65 years.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI, 0.723–0.786
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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