Recurrence of Nausea and Vomiting After Surgery
Author Information
Author(s): Eberhart Leopold HJ, Frank Silke, Lange Henning, Morin Astrid M, Scherag André, Wulf Hinnerk, Kranke Peter
Primary Institution: Philipps-University Marburg, Germany
Hypothesis
What is the incidence of recurrent postoperative nausea and vomiting after receiving placebo treatment?
Conclusion
The study found a high rate of recurrence of emetic symptoms after placebo, indicating a need for effective antiemetic treatment.
Supporting Evidence
- The recurrence rate of PONV was found to be between 65% and 84% after placebo treatment.
- The study included data from 29 trials.
- The findings highlight the need for effective antiemetic treatment in postoperative care.
- The study provides empirical estimates for future clinical trials.
- A total of 3608 patients were observed in the two unpublished trials.
Takeaway
After surgery, many patients feel sick again even if they don't get any medicine to help. This study shows that a lot of them will feel sick again after a while.
Methodology
A systematic review and meta-analysis of trials assessing the recurrence of postoperative nausea and vomiting after placebo treatment.
Potential Biases
Potential bias due to the reliance on placebo-controlled trials and the ethical concerns surrounding them.
Limitations
The study relies on existing literature, which may have variability in reporting and methodology.
Participant Demographics
Adult patients undergoing various surgical procedures.
Statistical Information
P-Value
p<0.05
Confidence Interval
95%-CI: 73%...91%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website