Manganese and Acute Paranoid Psychosis: A Case Report
Author Information
Author(s): Willem M Verhoeven, Jos I Egger, Harold J Kuijpers
Primary Institution: Vincent van Gogh Institute for Psychiatry, Centre of Excellence for Neuropsychiatry, Venray, The Netherlands
Hypothesis
Can manganese intoxication lead to acute paranoid psychosis?
Conclusion
Manganese intoxication can cause acute paranoid psychosis, which may be reversible with treatment.
Supporting Evidence
- The patient had elevated manganese serum levels indicating overexposure.
- Psychotic symptoms resolved within two weeks of treatment with risperidone.
- Follow-up MRI showed reduced signal intensity in the globus pallidus after treatment.
Takeaway
A man who worked with manganese developed sudden paranoid behavior, but after treatment, he got better.
Methodology
The case involved MRI scans and serum manganese level measurements to diagnose manganese intoxication.
Limitations
The study is based on a single case report, limiting generalizability.
Participant Demographics
49-year-old Caucasian male, welder with a history of manganese exposure.
Digital Object Identifier (DOI)
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