INTERLEUKIN-6 and reduced kidney function
1992
Serum levels of interleukin-6 are not dependent on the kidney function
Sample size: 21
publication
Evidence: moderate
Author Information
Author(s): L. Niissberger
Primary Institution: Lund University
Hypothesis
Does reduced kidney function affect serum levels of interleukin-6?
Conclusion
Serum levels of IL-6 are not dependent upon a reduced kidney function.
Supporting Evidence
- IL-6 levels do not correlate with kidney function as measured by serum creatinine.
- High correlation was found between Factor D and serum creatinine.
- IL-6 is produced in various conditions but is not significantly affected by kidney function.
Takeaway
This study found that having a sick kidney doesn't change the amount of a protein called IL-6 in the blood.
Methodology
Serum creatinine, Factor D, and soluble IL-2 receptor were measured using various techniques including ELISA.
Limitations
The study did not explore the effects of other potential factors influencing IL-6 levels.
Participant Demographics
Patients with adult polycystic kidney disease, all well except for their kidney disease.
Statistical Information
P-Value
p=0.0001
Statistical Significance
p<0.05
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