N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)formamide
2011
Crystal Structure of a Drug Intermediate
publication
Evidence: moderate
Author Information
Author(s): Wang Hao-Wei, Yang Ming-Ming, Lu Qi-Sheng, Li Fang-Shi
Primary Institution: Nanjing University of Technology
Conclusion
The crystal structure of N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)formamide was successfully determined, revealing a three-dimensional network stabilized by hydrogen bonds.
Supporting Evidence
- The dihedral angle between the pyrazole and benzene rings is 50.0°.
- Molecules are linked by intermolecular N—H⋯O hydrogen bonds.
- The study provides important structural information for drug synthesis.
Takeaway
Scientists studied a special compound that can help make medicines. They found out how its tiny parts are arranged in a solid form.
Methodology
The compound was prepared through a chemical reaction and its crystal structure was analyzed using X-ray diffraction.
Digital Object Identifier (DOI)
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