Increased fluoroquinolone resistance in E. coli over time
Author Information
Author(s): Boyd Lauren Becnel, Atmar Robert L, Randall Graham L, Hamill Richard J, Steffen David, Zechiedrich Lynn
Primary Institution: Baylor College of Medicine
Hypothesis
How do patient factors and time influence fluoroquinolone resistance in E. coli clinical isolates?
Conclusion
Fluoroquinolone resistance trends at a large urban hospital were not predicted by large surveillance programs.
Supporting Evidence
- Fluoroquinolone resistance increased significantly with time.
- Resistance was higher in males than females, particularly in urinary isolates.
- Resistance increased with patient age, with 3% in pediatric patients.
- Sputum samples had the highest frequency of resistance at ~30%.
Takeaway
Doctors found that more and more E. coli bacteria are becoming resistant to a common antibiotic over time, especially in older patients and males.
Methodology
Data from antibiograms for E. coli isolated between 1999 to 2004 were analyzed using Chi Square, Bonferroni, and Multiple Linear Regression methods.
Potential Biases
Potential bias due to the demographic characteristics of the patient population at the hospital.
Limitations
The study was retrospective and focused on a single hospital, which may not represent broader trends.
Participant Demographics
The patient population was largely indigent and ethnically diverse, with a higher number of female patients.
Statistical Information
P-Value
p<0.001
Confidence Interval
99%
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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