Necrotising colitis related to clozapine? A rare but life threatening side effect
2007
Necrotising colitis related to clozapine: A case report
Sample size: 1
publication
Evidence: low
Author Information
Author(s): Leong Quor M, Wong Kutt S, Koh Dean C
Primary Institution: Tan Tock Seng Hospital, Singapore
Hypothesis
Can clozapine usage lead to necrotising colitis?
Conclusion
Clozapine can cause life-threatening necrotising colitis, especially in patients with constipation and abdominal pain.
Supporting Evidence
- Clozapine is known to have anticholinergic activity.
- Patients on clozapine can experience gastrointestinal symptoms like constipation.
- Necrotising colitis has been linked to medications with anticholinergic effects.
Takeaway
A man got very sick from a medicine called clozapine, which made his belly hurt and caused a serious problem in his intestines. Doctors had to do surgery to help him.
Methodology
Case report detailing the patient's symptoms, treatment, and surgical intervention.
Limitations
Only one case is reported, limiting generalizability.
Participant Demographics
34-year-old Chinese male with a history of chronic schizophrenia.
Digital Object Identifier (DOI)
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