Letrozole vs Natural Cycles in Ovarian Stimulation
Author Information
Author(s): Bedaiwy Mohamed A, Abdelaleem Mahmoud A, Hussein Mostafa, Mousa Noha, Brunengraber Lisa N, Casper Robert F
Primary Institution: University Hospitals Case Medical Center, Case Western Reserve University School of Medicine
Hypothesis
Letrozole-treated cycles mimic natural cycles in hormonal and endometrial parameters.
Conclusion
Letrozole treatment leads to increased folliculogenesis and higher pregnancy rates compared to natural cycles.
Supporting Evidence
- Letrozole resulted in higher pregnancy rates compared to natural cycles.
- Endometrial thickness was similar between letrozole and natural cycles.
- Follicular dynamics showed more follicles in letrozole-treated groups.
Takeaway
This study found that using letrozole can help women get pregnant more easily than just waiting for natural cycles.
Methodology
A retrospective cohort study comparing hormonal and follicular dynamics in 208 patients undergoing IUI.
Potential Biases
Potential biases due to the retrospective nature and lack of randomization.
Limitations
The study is retrospective, non-powered, non-randomized, and not blinded.
Participant Demographics
208 infertile patients, average age around 34 years.
Statistical Information
P-Value
p = 0.02
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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