Treatment Outcomes in High-Risk Stage 1 Endometrial Cancer
Author Information
Author(s): Viani Gustavo A, Patia Barbara F, Pellizzon Antonio C, De Melo Marcel D, Novaes Paulo E, Fogaroli Ricardo C, Conte Maria A, Salvajoli Joao V
Primary Institution: Hospital do Cancer, Sao Paulo, Brazil
Hypothesis
What are the relapse and survival rates for high-risk patients with stage IC and IB grade 3 endometrial cancer?
Conclusion
The study found that stage IC, grade 2, 3 and IB grade 3 endometrial cancer is associated with a significantly increased risk of distant relapse and related death.
Supporting Evidence
- Five-year overall survival was 78.5% and event-free survival was 72.4%.
- Locoregional control rate was 92.4% at five years.
- Distant site failure was the most common initial failure site at 73.3%.
Takeaway
This study looked at patients with a specific type of cancer and found that those with higher risk had a greater chance of their cancer coming back and causing death.
Methodology
The study analyzed medical records of 106 patients treated surgically and with postoperative radiotherapy from 1993 to 2003.
Potential Biases
Potential biases may arise from the retrospective nature of the study and selection criteria for treatment.
Limitations
The study is limited by its retrospective design and the specific patient population analyzed.
Participant Demographics
Median age was 65 years, with a range of 32 to 83 years; 42.5% underwent lymph node dissection.
Statistical Information
P-Value
p < 0.0001
Confidence Interval
95% CI 29.7 – 79.7
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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