BORIS Expression in Breast Tumours
Author Information
Author(s): D'Arcy V, Pore N, Docquier F, Abdullaev Z K, Chernukhin I, Kita G-X, Rai S, Smart M, Farrar D, Pack S, Lobanenkov V, Klenova E
Primary Institution: University of Essex
Hypothesis
Is BORIS present in breast tumours and does it correlate with clinical/pathological parameters?
Conclusion
BORIS is expressed in 70.7% of breast tumours and correlates with high levels of progesterone and oestrogen receptors.
Supporting Evidence
- BORIS was detected in all 18 breast cell lines tested.
- BORIS was found in 70.7% of breast tumours.
- High levels of BORIS correlated with high levels of progesterone receptor and oestrogen receptor.
- BORIS can activate the promoters of the progesterone and oestrogen receptor genes.
Takeaway
BORIS is a protein found in many breast cancer tumours, and it might help doctors understand and treat the disease better.
Methodology
The study used immunohistochemical staining, western blot, and real-time RT-PCR to assess BORIS expression in breast tissues.
Limitations
The study did not explore the presence of BORIS in all breast cancer types and the correlation with other clinical parameters was limited.
Participant Demographics
Patients treated at Colchester General Hospital, with various breast cancer types.
Statistical Information
P-Value
p<0.0002
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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