Predicting Sepsis in ICU Patients Using Inflammatory Biomarkers
Author Information
Author(s): Muacevic Alexander, Adler John R, Chandrabhatla Balasubrahmanyam, A V Anitha, Puvvula Lakshmi Sasidhar, Gopal Palepu B
Primary Institution: Citizens Specialty Hospital, Hyderabad, IND
Hypothesis
Can inflammatory biomarkers improve the prediction of sepsis in ICU patients?
Conclusion
Easily accessible biomarkers from routine blood tests, especially MDW and MMV, can help diagnose sepsis early in resource-limited settings.
Supporting Evidence
- CRP and MDW were the most sensitive biomarkers for sepsis prediction.
- MDW had the highest specificity at 100%.
- 82% of patients had organ failure.
- Overall mortality rate was 9.5%.
- MDW and MMV were statistically significant in predicting sepsis.
Takeaway
Doctors can use simple blood tests to find out if someone in the ICU has sepsis, which is a serious infection. This helps them start treatment faster.
Methodology
A prospective observational study was conducted in an ICU over one year, analyzing six inflammatory biomarkers in patients.
Limitations
The study was not sufficiently powered to predict mortality differences and had a small sample size.
Participant Demographics
Mean age of 65.83 years, 59.5% male, 67.85% had three or more comorbidities.
Statistical Information
P-Value
0.028 for MDW, 0.046 for MMV
Confidence Interval
AUC for MDW was 0.932
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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