Genetics and Rapid Brain Connectivity Changes
Author Information
Author(s): Suhnyoung Jun, Alderson Thomas H., Malone Stephen M., Harper Jeremy, Hunt Ruskin H., Thomas Kathleen M., Iacono William G., Wilson Sylia, Sadaghiani Sepideh
Primary Institution: University of Illinois Urbana-Champaign
Hypothesis
Are rapid electrophysiological connectome dynamics subject-specific brain traits influenced by genetics?
Conclusion
Genetic factors significantly influence the rapid dynamics of brain connectivity, particularly in temporal features.
Supporting Evidence
- Genetic effects explained a substantial proportion of the phenotypic variance of temporal features.
- Fractional Occupancy in beta and gamma bands showed significant heritability.
- Transition Probability in theta, alpha, beta, and gamma bands was also found to be heritable.
- No evidence for the heritability of dynamic spatial features was found.
Takeaway
This study found that how our brains connect and communicate quickly can be influenced by our genes, especially in how long they stay in certain states and how often they switch between them.
Methodology
The study used source-localized EEG data from twins to assess the heritability of connectome dynamics using hidden Markov models.
Limitations
The study did not find heritability in spatial features of connectome dynamics, suggesting that genetics may not influence how states are spatially organized.
Participant Demographics
928 participants, 473 females, aged 23-40 years.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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