Effects of Brassica nigra Sprout Extract on Rat Health
Author Information
Author(s): Barakat Hassan, Aljutaily Thamer, Alkhurayji Raghad I., Aljumayi Huda, Alhejji Khalid S., Almutairi Sami O.
Primary Institution: Qassim University
Hypothesis
Does Brassica nigra sprout hydroalcoholic extract have protective effects on lipid homeostasis, hepatotoxicity, and nephrotoxicity in rats induced by cyclophosphamide?
Conclusion
Brassica nigra sprout extract may help improve lipid levels and protect liver and kidney functions in rats exposed to cyclophosphamide.
Supporting Evidence
- BNSE at 500 mg/kg significantly improved liver function and lipid profiles in rats.
- Rats treated with BNSE showed reduced levels of triglycerides, cholesterol, and liver enzymes.
- BNSE demonstrated nephroprotective effects by lowering creatinine and urea levels in treated rats.
- Improvements in organ weights were observed in rats receiving BNSE compared to those treated with cyclophosphamide alone.
Takeaway
This study found that a plant extract from Brassica nigra can help keep the body healthy by protecting the liver and kidneys and lowering bad fats in the blood.
Methodology
The study involved four groups of rats treated with different doses of cyclophosphamide and Brassica nigra sprout extract, followed by various biochemical tests to assess liver and kidney function.
Limitations
The study was conducted only on rats, and further clinical trials are needed to confirm the findings in humans.
Participant Demographics
Adult male Wistar albino rats aged 6-8 weeks and weighing 180-200 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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