Genomic imprinting in mammals: Emerging themes and established theories
2006
Genomic Imprinting in Mammals: Themes and Theories
publication
Evidence: moderate
Author Information
Author(s): Andrew J. Wood, Rebecca J. Oakey
Primary Institution: King's College London
Hypothesis
What role does genomic imprinting play in mammalian evolution?
Conclusion
Genomic imprinting is influenced by various evolutionary forces and is essential for proper gene expression and development in mammals.
Supporting Evidence
- Imprinted genes are expressed from only one parental allele due to differential epigenetic marks.
- Approximately half of the known imprinted genes are located on Chromosome 7.
- Imprinting can affect both embryonic development and postnatal traits.
Takeaway
Some genes in mammals only work if they come from one parent, not both. This special way of using genes is called genomic imprinting.
Methodology
The review discusses various studies and technologies used to identify and understand imprinted genes in the mouse genome.
Limitations
The review does not cover all related work due to space constraints.
Digital Object Identifier (DOI)
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