Decreasing of p27Kip1 and cyclin E protein levels is associated with progression from superficial into invasive bladder cancer
2001
Protein Levels and Bladder Cancer Progression
Sample size: 145
publication
Evidence: high
Author Information
Author(s): Kamai T, Takagi K, Asami H, Ito Y, Oshima H, Yoshida K-I
Primary Institution: Department of Urology, Dokkyo University School of Medicine, Tochigi, Japan
Hypothesis
Decreased levels of p27Kip1 and cyclin E proteins are associated with the progression of bladder cancer.
Conclusion
Lower levels of p27 and cyclin E proteins are linked to worse outcomes in bladder cancer patients.
Supporting Evidence
- Low protein levels of p27 were associated with high Ki-67 index and poorly differentiated grade.
- Low staining of cyclin E correlated with muscle invasion and lymph node metastasis.
- Patients with low p27 staining had a shorter disease-free and overall survival.
Takeaway
If the levels of certain proteins in bladder cancer patients are low, it might mean their cancer is getting worse.
Methodology
The study used immunohistochemical staining to analyze protein levels in bladder cancer patients.
Participant Demographics
145 consecutive Japanese patients with transitional cell carcinoma of the bladder.
Statistical Information
P-Value
P = 0.0002
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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