Understanding Sex Assignment in Children with Genital Ambiguity
Author Information
Author(s): Santos Henrique C., Barros Beatriz A., El-Beck Mayra S., Miranda Marcio L., Guaragna Mara S., Fabbri-Scallet Helena, Mazzola Taís N., Vieira Tarsis P., Mello Maricilda P., Marques-de-Faria Antonia P., Maciel-Guerra Andrea T., Guerra-Junior Gil
Primary Institution: Universidade Estadual de Campinas (UNICAMP)
Hypothesis
The study aims to verify the association between the definition of sex of rearing and clinical and cytogenetic features among patients with genital ambiguity.
Conclusion
Clinical and cytogenetic data were strongly associated with the definition of the sex of rearing of children with genital ambiguity referred to a DSD center without sex assignment.
Supporting Evidence
- 74 patients were reared as males and 59 as females.
- Palpable gonads and more virilized genitalia were strong predictors for defining male sex.
- 58% of patients over 18 had a gender identity in accordance with the sex of rearing.
Takeaway
This study looked at children with unclear genitalia and found that certain medical features can help doctors decide if a child should be raised as a boy or a girl.
Methodology
The study reviewed medical records of 133 patients with genital ambiguity to analyze clinical and cytogenetic features related to sex of rearing.
Potential Biases
Potential bias in the interpretation of clinical data and the influence of cultural factors on sex assignment decisions.
Limitations
The study is retrospective and relies on existing medical records, which may have incomplete information.
Participant Demographics
Patients included both males and females with genital ambiguity, with a focus on those referred to a DSD center.
Statistical Information
P-Value
0.0001
Confidence Interval
95%CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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