How Maternal Overweight Affects the Umbilical Vein
Author Information
Author(s): Souza Kamilla Batista da Silva, Hochberger Luana Caroline, Castrignano Camargo Felippe Egon, Silva Gabriely Santos, Camargo Giovanna Castrignano, Mello João Pedro Lourenço, Alcantara Dos Santos Fernanda Cristina, Giachini Fernanda Regina, Lobato Núbia de Souza, Souto Paula Cristina de Souza
Primary Institution: Federal University of Mato Grosso
Hypothesis
Does pregestational maternal overweight alter the structural characteristics of the umbilical vein?
Conclusion
Maternal overweight leads to structural changes in the umbilical vein, including increased thickness and collagen deposition.
Supporting Evidence
- Veins from overweight pregnant women had greater total area and wall thickness.
- Higher collagen deposition was observed in the perivascular region of the overweight group.
- A positive correlation was found between BMI and vessel thickness.
Takeaway
Being overweight before pregnancy can change the umbilical vein, making it thicker and affecting how it works.
Methodology
Umbilical cords were collected from eutrophic and overweight pregnant women, and histological analyses were performed to assess structural characteristics.
Limitations
The study had a limited sample size and did not differentiate between degrees of overweight and obesity.
Participant Demographics
Pregnant women aged 18 and older, with live newborn deliveries and no fetal malformations.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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