Effects of Adenosine on Breathing in Asthma
Author Information
Author(s): Burki Nausherwan K, Alam Mahmud, Lee Lu-Yuan
Primary Institution: University of Connecticut Health Center
Hypothesis
Intravenous adenosine may increase dyspnea and cause bronchospasm in asthmatic subjects.
Conclusion
Intravenous adenosine does not cause bronchospasm in asthmatic subjects, but it does increase the intensity of dyspnea.
Supporting Evidence
- Adenosine caused a significant increase in heart rate and minute ventilation in both groups.
- The intensity of dyspnea was significantly greater in asthmatic subjects compared to normal subjects.
- Placebo injection had no significant effect on respiratory parameters.
Takeaway
This study found that a medicine called adenosine makes people with asthma feel more short of breath, but it doesn't actually tighten their airways.
Methodology
The study compared the effects of placebo and 10 mg intravenous adenosine in 6 normal and 6 asthmatic subjects.
Participant Demographics
6 normal subjects and 6 asthmatic subjects, all non-smokers; asthmatic subjects had a mean age of 40 years.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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