Latent Tuberculosis in HIV Positive Patients
Author Information
Author(s): Brock Inger, Ruhwald Morten, Lundgren Bettina, Westh Henrik, Mathiesen Lars R, Ravn Pernille
Primary Institution: University Hospital Hvidovre
Hypothesis
What is the prevalence of latent tuberculosis infection among HIV positive individuals using the QFT-IT test?
Conclusion
The study found a 4.6% prevalence of latent TB infection among HIV positive individuals, with higher rates in those with known exposure or residency in high endemic areas.
Supporting Evidence
- 27 out of 590 HIV positive individuals tested positive for latent TB.
- 78% of QFT-IT positive patients had risk factors for TB.
- The prevalence of latent TB was 16% among those with known TB exposure.
Takeaway
The researchers tested 590 HIV positive people for latent tuberculosis and found that about 5 out of every 100 had it, especially those who had been around TB before or lived in places where TB is common.
Methodology
The QFT-IT test was performed on 590 HIV positive individuals, and data on CD4 cell count and TB risk factors were collected.
Potential Biases
Potential bias due to the exclusion of patients with indeterminate test results.
Limitations
The study did not perform TST in parallel with the QFT-IT test, which could have provided additional insights.
Participant Demographics
{"median_age":43,"male_percentage":74,"ethnicities":{"Danish":74,"Non-Danish European":4,"North American":1,"African":13,"Asian":5,"Middle Eastern":2,"Latin American":1}}
Statistical Information
P-Value
0.00003
Confidence Interval
2.8–18.2
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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