Therapeutic Drug Monitoring of Low Methotrexate Doses
Author Information
Author(s): Kocur Arkadiusz, Mikulska Aleksandra, Moczulski Mateusz, Pawiński Tomasz
Primary Institution: Medical University of Warsaw
Hypothesis
The study aims to review the determination of methotrexate and its metabolites in clinical practice for therapeutic drug monitoring.
Conclusion
The review highlights the importance of methotrexate polyglutamates as biomarkers for drug exposure and adherence in low-dose methotrexate treatment.
Supporting Evidence
- Methotrexate polyglutamates are informative biomarkers of drug exposure.
- Therapeutic drug monitoring can help prevent toxicity and improve adherence.
- Chromatographic techniques are essential for accurate methotrexate measurement.
- Low-dose methotrexate is used for treating rheumatoid arthritis and other conditions.
Takeaway
This study looks at how doctors can check if patients are taking their methotrexate medicine correctly and safely by measuring certain markers in their blood.
Methodology
The study is a review of published studies on methotrexate determination, focusing on pre-analytical variability, bioanalytical considerations, and clinical applications.
Limitations
The review is limited to studies published from 2010 to 2024 and may not cover all relevant literature.
Digital Object Identifier (DOI)
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