Development of pulmonary bronchiolo-alveolar adenocarcinomas in transgenic mice overexpressing murine c- myc and epidermal growth factor in alveolar type II pneumocytes
2001
Study of Lung Cancer in Mice
publication
Evidence: moderate
Author Information
Author(s): Ehrhardt A, Bartels T, Geick A, Klocke R, Paul D, Halter R
Primary Institution: Center for Medical Biotechnology, Fraunhofer Institute for Toxicology and Aerosol Research
Hypothesis
Transgenic mice overexpressing c-myc and epidermal growth factor will develop bronchiolo-alveolar adenocarcinomas.
Conclusion
The study found that c-myc and EGF cooperate in the formation of bronchiolo-alveolar adenocarcinomas in the lung.
Supporting Evidence
- Transgenic lines expressing c-myc developed multifocal bronchiolo-alveolar hyperplasias, adenomas, and carcinomas.
- Transgenic lines expressing IgEGF developed hyperplasias of the alveolar epithelium.
- The average life expectancies of hemizygous and homozygous c-myc transgenics were 14.25 months and 9.2 months, respectively.
- Double transgenics hemizygous for both c-myc and IgEGF developed bronchiolo-alveolar adenocarcinomas at an average age of 9 months.
Takeaway
Scientists created special mice to see how certain genes cause lung cancer, and they found that two genes work together to make the cancer happen.
Methodology
Transgenic mouse models were established to study tumorigenesis of bronchiolo-alveolar adenocarcinomas.
Digital Object Identifier (DOI)
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