Serotonin transporter gene and functional dyspepsia in Japan
Author Information
Author(s): Toyoshima Fumihiko, Oshima Tadayuki, Nakajima Shigemi, Sakurai Jun, Tanaka Junji, Tomita Toshihiko, Hori Kazutoshi, Matsumoto Takayuki, Miwa Hiroto
Primary Institution: Hyogo College of Medicine
Hypothesis
The association between serotonin transporter (SERT) gene polymorphism and functional dyspepsia (FD) was explored.
Conclusion
The results suggest that the 5-HTTLPR L allele may influence the susceptibility to postprandial distress syndrome (PDS).
Supporting Evidence
- The study included 77 subjects with uninvestigated dyspepsia and 646 healthy controls.
- The SL genotype was significantly associated with PDS with an odds ratio of 2.24.
- No significant correlation was found between the 5-HTTLPR genotype and overall FD phenotype.
Takeaway
This study looked at how a specific gene might affect stomach problems in people from Japan, finding a link between one gene variant and a type of stomach discomfort.
Methodology
Subjects were divided into PDS and EPS groups, and the SLC6A4 polymorphism was evaluated using logistic regression analysis.
Potential Biases
No significant bias was found between the groups for sex, smoking habit, and drinking habit.
Limitations
The sample size was relatively small, and the age differences between groups may affect the results.
Participant Demographics
The median age of subjects with dyspepsia was 52 years, and 45 years for controls.
Statistical Information
P-Value
0.034
Confidence Interval
1.16-4.32
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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