TCF7L2 Gene Variants and Diabetes in Tropical Calcific Pancreatitis
Author Information
Author(s): Mahurkar Swapna, Bhaskar Seema, Reddy D Nageshwar, Prakash Swami, Rao G Venkat, Singh Shivaram Prasad, Thomas Varghese, Chandak Giriraj Ratan
Primary Institution: Centre for Cellular and Molecular Biology
Hypothesis
TCF7L2 variants should show similar association if diabetes in FCPD is similar to T2D.
Conclusion
TCF7L2 variants are not associated with diabetes in TCP, suggesting that diabetes in TCP patients may not be similar to T2D.
Supporting Evidence
- No significant association of TCF7L2 SNPs was observed with TCP or FCPD.
- The minor allele frequency for rs7903146 was different between TCP and FCPD patients carrying the N34S SPINK1 variant but did not reach statistical significance.
- A statistically significant association was found between TCF7L2 variants and FCPD patients carrying the L26V allele.
Takeaway
The study looked at whether certain gene variations are linked to diabetes in people with a specific type of pancreatitis, but found no connection.
Methodology
Analyzed two TCF7L2 polymorphisms in 478 TCP patients and 661 healthy controls using direct sequencing and chi-square tests.
Limitations
The study may need to be replicated in larger sample sizes due to the possibility of chance associations.
Participant Demographics
478 TCP patients (320 males, 158 females) and 661 healthy controls (332 males, 329 females) from Dravidian and Indo-European ethnicities.
Statistical Information
P-Value
0.09 for rs7903146, 0.013 for L26V CTSB
Confidence Interval
95% CI = 0.93–2.70 for rs7903146, 95% CI = 1.11–2.56 for L26V CTSB
Statistical Significance
p>0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website