Canis lupus familiaris and diclofenac: understanding the potential risks of this association
2024

Risks of Diclofenac for Dogs

publication Evidence: moderate

Author Information

Author(s): Lohmann-Menezes Bruna, Giarolla Jeanine, da Silva-Santos Yasmin, Petri Giuliana, Epiphanio Sabrina

Primary Institution: University of São Paulo, São Paulo, Brazil

Hypothesis

What are the potential risks associated with diclofenac use in dogs?

Conclusion

Diclofenac can cause significant gastrointestinal and other organ damage in dogs, highlighting the need for veterinary guidance before administration.

Supporting Evidence

  • Diclofenac is contraindicated in dogs due to its potential for gastrointestinal and renal toxicity.
  • Reports indicate that the gastrointestinal tract is the most affected organ system in dogs exposed to diclofenac.
  • Veterinary pharmacovigilance is essential for monitoring adverse reactions to medications in animals.

Takeaway

Giving dogs diclofenac can make them very sick, especially their stomachs, so it's important to ask a vet before giving them any medicine.

Methodology

This narrative review consulted scientific publications, books, case reports, and inquiries with regulatory agencies regarding diclofenac's effects on dogs.

Potential Biases

Potential bias exists due to reliance on available literature and reports, which may not represent all cases.

Limitations

The review may not capture all adverse reactions as many incidents go unreported, especially those involving off-label use.

Digital Object Identifier (DOI)

10.3389/fvets.2024.1507390

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