Case report: Complete response in TMB-H advanced uterine clear cell carcinoma: a case analysis of paclitaxel albumin-bound combined with PD-1/CTLA-4 bispecific antibody
2024

Complete Response in Advanced Uterine Clear Cell Carcinoma: A Case Analysis

Sample size: 1 publication Evidence: low

Author Information

Author(s): Chen Yue, Zhou Wenting, Wang Yili

Primary Institution: The Oncology Department of the First Affiliated Hospital of Gannan Medical University

Hypothesis

Can a combination of paclitaxel albumin-bound and PD-1/CTLA-4 bispecific antibody effectively treat advanced uterine clear cell carcinoma?

Conclusion

The combination treatment led to a complete response in a patient with advanced uterine clear cell carcinoma, suggesting its potential effectiveness.

Supporting Evidence

  • The patient achieved complete remission after treatment with cadonilimab and albumin-bound paclitaxel.
  • The treatment was well-tolerated despite some adverse effects.
  • The patient's response was maintained during follow-up examinations.

Takeaway

A woman with a tough type of cancer got better after using a special medicine combined with chemotherapy, showing that new treatments can work well.

Methodology

The patient received a combination of cadonilimab and albumin-bound paclitaxel for six cycles, followed by cadonilimab monotherapy.

Limitations

The study is based on a single case report, limiting generalizability.

Participant Demographics

49-year-old female with a history of atrial fibrillation and advanced uterine clear cell carcinoma.

Digital Object Identifier (DOI)

10.3389/fimmu.2024.1486200

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