Aortitis Induced by Granulocyte-Colony Stimulating Factor
Author Information
Author(s): Zhao Ting, Xu Huanhuan
Primary Institution: Department of Clinical Pharmacy, Weifang People’s Hospital, Shandong Second Medical University, Weifang, China
Hypothesis
What are the clinical characteristics and implications of G-CSF-induced aortitis?
Conclusion
G-CSF-induced aortitis can occur not only in cancer patients but also in healthy stem cell donors, with asymptomatic cases posing a risk of being overlooked.
Supporting Evidence
- G-CSF-induced aortitis was primarily found in patients with underlying malignancies, especially breast cancer.
- Most patients had a good prognosis, but some developed complications.
- CT scans showed that aortitis most commonly occurred in the aortic arch and its branches.
Takeaway
Some medicines can cause a serious problem called aortitis, which is inflammation of the aorta, and this can happen even to healthy people who donate stem cells.
Methodology
Case reports of adverse reactions of aortitis induced by G-CSF were collected and analyzed descriptively.
Potential Biases
Potential reporting bias in the collection of case reports.
Limitations
The study relies on case reports, which may not capture all instances of G-CSF-induced aortitis.
Participant Demographics
The sample included 58 females and 14 males, with a mean age of 61.83 years.
Digital Object Identifier (DOI)
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