Polysaccharide from Radix Pseudostellariae Helps Mice with Chronic Fatigue Syndrome
Author Information
Author(s): Sheng Rong, Xu Xianxiang, Tang Qin, Bian Difei, Li Ying, Qian Cheng, He Xin, Gao Xinghua, Pan Rong, Wang Chong, Luo Yubin, Xia Yufeng, Dai Yue
Primary Institution: China Pharmaceutical University
Hypothesis
The study aims to examine the effect of polysaccharide isolated from Radix Pseudostellariae on chronic fatigue syndrome induced in mice.
Conclusion
Polysaccharide from Radix Pseudostellariae significantly alleviated symptoms of chronic fatigue syndrome in mice.
Supporting Evidence
- PRP increased the body weights of mice after poly I:C injection.
- PRP prolonged the forced swimming time of mice, indicating reduced fatigue.
- PRP improved spontaneous activity in mice after poly I:C treatment.
- PRP decreased the number of errors in learning ability tests in mice.
- PRP elevated serum corticosterone levels in a dose-dependent manner.
- PRP modulated the CD4+/CD8+ T lymphocyte ratio in peripheral blood.
Takeaway
This study found that a special sugar from a plant can help tired mice feel better and more active.
Methodology
Mice were divided into groups and given different doses of polysaccharide before being induced with chronic fatigue using poly I:C, followed by various tests to measure fatigue and immune response.
Limitations
The study was conducted only on mice, and results may not directly translate to humans.
Participant Demographics
Male ICR mice, weighing 18-22g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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