Stroke Risk and Cognitive Function Study
Author Information
Author(s): Llewellyn David J, Lang Iain A, Xie Jing, Huppert Felicia A, Melzer David, Langa Kenneth M
Primary Institution: University of Cambridge
Hypothesis
The study aims to examine the relationship between 10-year risk for incident stroke and cognitive function in a large population-based sample.
Conclusion
High subclinical cerebrovascular disease burden was associated with worse cognitive function in multiple domains among individuals free from a history of stroke or dementia.
Supporting Evidence
- 10 percentage point increments of 10-year stroke risk were associated with poor global cognitive function.
- The association with stroke risk remained significant for global cognitive function after adjustments.
- Men had a higher 10-year risk of stroke than women.
Takeaway
If you have a higher risk of having a stroke, it might mean your thinking and memory skills are not as good.
Methodology
The study used a modified Framingham Stroke Risk Profile to assess stroke risk and linear regression models to analyze cognitive function in participants aged 50 and over.
Potential Biases
Self-reported medical conditions may introduce bias, and the cross-sectional design limits causal inferences.
Limitations
The study was limited to community living individuals and excluded those with a history of stroke or dementia, which may affect generalizability.
Participant Demographics
Participants were adults aged 50 years and over, with a mix of men and women, and included various socioeconomic backgrounds.
Statistical Information
P-Value
< 0.001
Confidence Interval
95% CI -0.434 – -0.376
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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