Genetic lineage tracing defines distinct neurogenic and gliogenic stages of ventral telencephalic radial glial development
2008
Understanding Radial Glial Development and Function
publication
Evidence: high
Author Information
Author(s): Anthony Todd, Nathaniel Heintz
Primary Institution: The Rockefeller University
Hypothesis
Are radial glial cells the main source of neurons in the developing brain?
Conclusion
Radial glia are the primary neuronal progenitors in the developing central nervous system, with distinct neurogenic and gliogenic stages.
Supporting Evidence
- Most neurons in the brain are derived from radial glia.
- Radial glia transition from a neurogenic to a gliogenic stage during development.
- The hGFAP promoter is not active until after radial glial neurogenesis is largely completed.
Takeaway
Radial glial cells help make most of the brain's neurons, and they go through different stages as they develop.
Methodology
The study used Cre/loxP lineage tracing with different radial glial promoters to analyze the neurogenic potential of radial glia.
Limitations
The study may not account for all regional differences in radial glial function and the timing of promoter activity.
Digital Object Identifier (DOI)
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