Cortical-spreading depression: at the razor’s edge of scientific logic
2011
Cortical-spreading depression: at the razor’s edge of scientific logic
Editorial
Author Information
Author(s): Vinod Kumar Gupta
Primary Institution: Migraine-Headache Institute, S-407, Greater Kailash-II, New Delhi, 110 048 India
Conclusion
Cortical spreading depression (CSD) may not be a useful model for understanding migraine and could be misleading in headache research.
Supporting Evidence
- Cortical spreading depression has been a topic of fascination for over 60 years in headache research.
- Flunarizine can alleviate cerebral mitochondrial injury but its role in migraine treatment is uncertain.
- Evidence supporting flunarizine's effectiveness for migraine prophylaxis is sparse.
Takeaway
Cortical spreading depression is a concept in headache research that might not help us understand migraines, and it could be time to move on from it.
Potential Biases
The reliance on CSD in migraine research may lead to flawed conclusions due to its uncertain role in migraine therapeutics.
Limitations
The limitations of CSD as a model for human neurological illnesses, particularly migraine, have been extensively discussed.
Digital Object Identifier (DOI)
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