BMP-7 in Gastric Cancer
Author Information
Author(s): Aoki M, Ishigami S, Uenosono Y, Arigami T, Uchikado Y, Kita Y, Kurahara H, Matsumoto M, Ueno S, Natsugoe S
Primary Institution: Kagoshima University School of Medicine
Hypothesis
The study investigates the expression of BMP-7 in gastric cancer and its clinical significance.
Conclusion
BMP-7 expression can be used as a strong predictor of the risk of tumor recurrence in gastric cancer.
Supporting Evidence
- BMP-7 expression was identified in cellular membranes and cytoplasm of cancer cells.
- BMP-7-positive expression was found in 129 of 233 patients (55%).
- BMP-7 expression correlated with tumor size, nodal involvement, lymphatic invasion, and venous invasion.
- BMP-7 expression was significantly correlated with patient postoperative outcome, especially in the undifferentiated group.
- Multivariate analysis revealed BMP-7 expression as one of the independent prognostic factors.
Takeaway
This study found that a protein called BMP-7 is present in many gastric cancer patients and can help doctors predict how likely the cancer is to come back after treatment.
Methodology
The study used immunohistochemistry to investigate BMP-7 expression in gastric cancer tissues from 233 patients.
Participant Demographics
The study included 233 gastric cancer patients, 161 males and 72 females, aged 31 to 85 years, with an average age of 66.
Statistical Information
P-Value
p<0.01
Confidence Interval
95% Confidence interval: 1.524–5.648
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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