Improving Ketamine HCl Solubility for Nasal Delivery
Author Information
Author(s): Idoudi Sourour, Saleh Alaaeldin, Akkbik Mohammed, Amine Leena, Alansari Khalid, Rachid Ousama, Alkilany Alaaldin M.
Primary Institution: Qatar University
Hypothesis
This study investigates solubilizing strategies to enhance the aqueous solubility of ketamine HCl for intranasal administration.
Conclusion
The study found that pH optimization and the use of surfactants like SDS can significantly improve the solubility of ketamine HCl for intranasal delivery.
Supporting Evidence
- Ketamine HCl solubility increased with medium acidity, with pH 3.5 being optimal.
- 1% SDS was found to be the most effective surfactant for enhancing ketamine HCl solubility.
- Solubility screening revealed methanol as the most effective co-solvent, despite its toxicity.
Takeaway
The researchers looked for ways to make ketamine HCl dissolve better in water so it can be given through the nose more easily. They found that adjusting the acidity and using certain additives helped a lot.
Methodology
The study assessed the solubility of ketamine HCl by evaluating pH, co-solvents, and surfactants, and developed a UV-Vis spectroscopy method for analysis.
Limitations
The study did not conduct a systematic evaluation of the effects of buffer composition on solubility.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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