Efficacy and Safety of T. Angelica Herbal Tonic
Author Information
Author(s): Esimone Charles O., Akah Peter A., Nworu Chukwuemeka S.
Primary Institution: University of Nigeria, Nsukka
Hypothesis
What are the efficacy and safety of T. Angelica Herbal Tonic in relation to its label claims?
Conclusion
The study found that T. Angelica Herbal Tonic has some favorable pharmacological effects and lacks abortifacient and teratogenic properties.
Supporting Evidence
- TAHT did not cause lethality at doses above 5000 mg kg−1.
- TAHT improved gastrointestinal motility in a dose-dependent manner.
- TAHT showed no significant effect on acetylcholine, histamine, and nicotine-evoked contractions of guinea pig ileum.
- TAHT did not exhibit abortifacient or teratogenic properties in pregnant rats.
Takeaway
This study looked at a herbal tonic used in Nigeria and found it can help with digestion and is generally safe for use.
Methodology
The study involved administering T. Angelica Herbal Tonic to mice and rats to assess its effects on gastrointestinal motility, reproductive toxicity, and acute toxicity.
Potential Biases
Potential bias due to lack of controlled clinical trials on human subjects.
Limitations
The study was conducted on animal models, and results may not directly translate to humans.
Participant Demographics
Adult albino rats, albino mice, and guinea pigs of both sexes.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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