Complex Portal 2025: New Human Complexes and Visualization Tools
Author Information
Author(s): Balu Sucharitha, Huget Susie, Medina Reyes Juan Jose, Ragueneau Eliot, Panneerselvam Kalpana, Fischer Samantha N, Claussen Erin R, Kourtis Savvas, Combe Colin W, Meldal Birgit H M, Perfetto Livia, Rappsilber Juri, Kustatscher Georg, Drew Kevin, Orchard Sandra, Hermjakob Henning
Primary Institution: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI)
Hypothesis
How can we enhance the understanding of human protein complexes through improved data curation and visualization tools?
Conclusion
The Complex Portal has significantly increased its coverage of human protein complexes and introduced new visualization tools for better comparison and analysis.
Supporting Evidence
- The Complex Portal now includes over 2150 manually curated human complexes.
- An additional 14,964 machine-learning predicted complexes have been integrated.
- New visualization tools like the Complex Navigator have been developed for better comparison of complexes.
Takeaway
The Complex Portal helps scientists understand how proteins work together by providing a big database of protein complexes and tools to visualize them.
Methodology
The study involved manual curation of protein complexes and integration of machine-learning predicted complexes into the Complex Portal.
Limitations
The study may be limited by the reliance on machine-learning predictions and the need for ongoing manual curation to validate new complexes.
Digital Object Identifier (DOI)
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