Hematopoietic Stem Cells and Lymphatic Endothelium
Author Information
Author(s): Jiang Shuguang, Bailey Alexis S., Goldman Devorah C., Swain John R., Wong Melissa H., Streeter Philip R., Fleming William H.
Primary Institution: Oregon Health & Science University
Hypothesis
Do hematopoietic stem cells (HSCs) have the potential to give rise to lymphatic endothelial cells (LEC)?
Conclusion
Hematopoietic stem cells can contribute to both normal and tumor-associated lymphatic endothelium.
Supporting Evidence
- Hematopoietic stem cells were shown to integrate into lymphatic vessels in multiple tissues.
- Donor-derived lymphatic endothelial cells persisted for over 12 months.
- Transplantation of HSCs into tumor models demonstrated their contribution to tumor-associated lymphatics.
Takeaway
This study shows that certain blood cells can turn into cells that make up the lymphatic system, which helps with fluid balance and immune function.
Methodology
Marked HSCs were transferred into irradiated mice, and the presence of donor-derived LECs was evaluated in various tissues over time.
Limitations
The study primarily focused on mouse models, which may not fully represent human biology.
Digital Object Identifier (DOI)
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