Kidney Cancer Risk Factors in Central and Eastern Europe
Author Information
Author(s): Brennan P, van der Hel O, Moore L E, Zaridze D, Matveev V, Holcatova I, Janout V, Kollarova H, Foretova L, Szeszenia-Dabrowska N, Mates D, Rothman N, Boffetta P, Chow W-H
Primary Institution: International Agency for Research on Cancer (IARC), Lyon, France
Hypothesis
What are the risk factors for kidney cancer in central and eastern Europe?
Conclusion
Increased body mass index (BMI) and a history of hypertension are associated with a higher risk of kidney cancer in central and eastern Europe.
Supporting Evidence
- Increased BMI was positively associated with kidney cancer overall.
- A history of hypertension was linked to a higher risk of kidney cancer.
- The study included a large sample size from multiple countries.
Takeaway
Being overweight and having high blood pressure can make you more likely to get kidney cancer, especially in certain parts of Europe.
Methodology
A case-control study involving 1097 kidney cancer cases and 1476 controls across four central European countries.
Potential Biases
Potential bias due to the smoking prevalence among hospital controls.
Limitations
The study may not fully explain the high incidence of kidney cancer, indicating that other important causes remain to be discovered.
Participant Demographics
648 men and 449 women with kidney cancer cases; 952 men and 524 women as controls.
Statistical Information
P-Value
0.011
Confidence Interval
1.09, 1.75
Statistical Significance
p=0.011
Digital Object Identifier (DOI)
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