High-throughput SNP genotyping
Author Information
Author(s): Suzanne Jenkins, Neil Gibson
Primary Institution: R&D Genetics, AstraZeneca
Hypothesis
High-throughput SNP genotyping platforms are needed to meet the increasing demands of genetics research.
Conclusion
The next generation of high-throughput genotyping platforms will need to deliver one million genotypes per day at a lower cost and with minimal DNA requirements.
Supporting Evidence
- Current technology platforms can deliver over 100,000 genotypes per day with an accuracy of over 99%.
- Future platforms are expected to achieve throughputs of one million genotypes per day at a cost of only a few cents per genotype.
- High-throughput genotyping is essential for advancing pharmacogenetics research.
Takeaway
Scientists are trying to find faster and cheaper ways to test many genetic markers at once, which could help in understanding diseases better.
Methodology
The review discusses various chemistries and detection systems suitable for high-throughput SNP genotyping.
Limitations
Current technologies have high reagent costs and DNA template requirements, which may limit their future use.
Digital Object Identifier (DOI)
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