Protocol for MInimizing the Risk of Metachronous Adenomas of the CoLorectum with Green Tea Extract (MIRACLE): a randomised controlled trial of green tea extract versus placebo for nutriprevention of metachronous colon adenomas in the elderly population
2011

Green Tea Extract to Prevent Colon Adenomas

Sample size: 2534 publication 10 minutes Evidence: moderate

Author Information

Author(s): Julia C Stingl, Thomas Ettrich, Rainer Muche, Martina Wiedom, Jürgen Brockmöller, Angela Seeringer, Thomas Seufferlein

Primary Institution: University Ulm, Germany

Hypothesis

Does dietary supplementation with green tea extract reduce the recurrence of colon adenomas in elderly patients?

Conclusion

The study aims to validate the effectiveness of green tea extract in preventing the recurrence of colon adenomas.

Supporting Evidence

  • Green tea polyphenols have shown preventive effects in various studies.
  • Previous small studies indicated a reduction in adenoma recurrence with green tea extract.
  • The study design includes a large sample size to enhance reliability.

Takeaway

This study is testing if taking green tea extract can help stop colon growths from coming back in older people.

Methodology

A randomized, placebo-controlled trial comparing green tea extract with placebo over three years.

Potential Biases

Potential drop-out rates may affect the validity of the results.

Limitations

The follow-up period of three years may be too short to fully assess the long-term effects of the intervention.

Participant Demographics

Participants are elderly individuals aged 50-80 with a history of colorectal adenomas.

Statistical Information

P-Value

p<0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/1471-2407-11-360

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