Gene Polymorphisms and Atrial Fibrillation Risk
Author Information
Author(s): Giusti Betti, Gori Anna Maria, Marcucci Rossella, Sestini Ilaria, Saracini Claudia, Sticchi Elena, Gensini Francesca, Fatini Cinzia, Abbate Rosanna, Gensini Gian Franco
Primary Institution: University of Florence, Florence, Italy
Hypothesis
Are C677T and A1298C MTHFR, A2756G MTR, and -786 C/T eNOS gene polymorphisms associated with the risk of Non-Valvular Atrial Fibrillation (NVAF)?
Conclusion
The four gene polymorphisms studied were not associated with an increased risk of NVAF, despite their influence on homocysteine levels.
Supporting Evidence
- Hcy levels were significantly higher in NVAF patients than in controls.
- Genotype distribution of the four polymorphisms did not differ between patients and controls.
- Significant association between Hcy levels and C677T MTHFR polymorphism was observed.
Takeaway
This study looked at whether certain genes affect the risk of a heart condition called atrial fibrillation, and found that they don't increase the risk, even though they can change homocysteine levels in the blood.
Methodology
456 NVAF patients and 912 matched controls were genotyped for specific gene polymorphisms using electronic microchip technology.
Limitations
The study lacked information on vitamin status, which could influence homocysteine levels.
Participant Demographics
456 NVAF patients (271 men, 185 women) and 912 matched controls (542 men, 370 women).
Statistical Information
P-Value
p<0.0001
Confidence Interval
95% CI 14.7–15.7 for patients, 95% CI 11.0–11.6 for controls
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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