Chronic Kidney Disease in Sri Lanka: Is Cadmium a Cause?
Author Information
Author(s): Wanigasuriya Kamani P, Peiris-John Roshini J, Wickremasinghe Rajitha
Primary Institution: University of Sri Jayewardenepura
Hypothesis
Is cadmium a likely cause of chronic kidney disease of unknown aetiology in Sri Lanka?
Conclusion
The study suggests that hypertension, diabetes, urinary tract infections, and smoking are significant risk factors for microalbuminuria, with a potential environmental link to cadmium exposure.
Supporting Evidence
- Microalbuminuria was detected in 6.1% of females and 8.5% of males.
- Smoking, alcohol use, hypertension, diabetes, and UTI were associated with microalbuminuria.
- Drinking well water in fields was linked to higher rates of microalbuminuria.
Takeaway
This study looked at people in Sri Lanka to see if certain habits and environmental factors might be causing kidney problems. They found that things like high blood pressure and drinking well water could be linked to these issues.
Methodology
The study involved randomly selected adults from the North Central Province of Sri Lanka, using questionnaires and urine tests to assess microalbuminuria.
Potential Biases
Potential confounding factors may have influenced the results, particularly regarding pesticide exposure.
Limitations
The study's cross-sectional design limits the ability to draw causal conclusions.
Participant Demographics
The sample included 425 females and 461 males, primarily farmers from low socio-economic backgrounds.
Statistical Information
P-Value
p < 0.001
Confidence Interval
95% CI for odds ratios provided in the results
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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